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The first line of evidence refers to experiments showing that systemic [36] or local [37] salsolinol administration elicits conditioned place preference, exerts alcohol-like motivational/sensitization effects [38, 39] and leads to excessive alcohol intake [39]

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For patients without HIV considering Tesamorelin for visceral fat or metabolic support, the investigational status means the evidence is mechanistic and derived from smaller studies and the HIV trial population, rather than from a dedicated phase 3 programme in a metabolic or non-HIV population